LM Economic Consortium
  • Certified Programs
  • For Employers
  • For Healthcare Providers
Menu
  • About
  •    The Why of the
       LMERC
  •    Who
  •    Advisory Board
  •    Staff
  • Benefits
  •    For Employers
  •    For Healthcare
       Providers
  •    For Individuals
  • Resources
    • Key Papers and Presentations
    • Certified Programs
Consulting Evidence Database Download Database
Home » Evidences » Biomarkers » Identifying biomarkers of dietary patterns by using metabolomics.

Identifying biomarkers of dietary patterns by using metabolomics.

Submitted by admin on Tue, 08/21/2018 - 17:39

Author(s):

Playdon, M. C., et al.

Year Published:

2017

Journal:

American Journal of Clinical Nutrition

Categories:

Biomarkers

Link to Abstract Summary:

https://www.ncbi.nlm.nih.gov/pubmed/28031192

Abstract:

BACKGROUND: Healthy dietary patterns that conform to national dietary guidelines are related to lower chronic disease incidence and longer life span. However, the precise mechanisms involved are unclear. Identifying biomarkers of dietary patterns may provide tools to validate diet quality measurement and determine underlying metabolic pathways influenced by diet quality. OBJECTIVE: The objective of this study was to examine the correlation of 4 diet quality indexes [the Healthy Eating Index (HEI) 2010, the Alternate Mediterranean Diet Score (aMED), the WHO Healthy Diet Indicator (HDI), and the Baltic Sea Diet (BSD)] with serum metabolites. DESIGN: We evaluated dietary patterns and metabolites in male Finnish smokers (n = 1336) from 5 nested case-control studies within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort. Participants completed a validated food-frequency questionnaire and provided a fasting serum sample before study randomization (1985-1988). Metabolites were measured with the use of mass spectrometry. We analyzed cross-sectional partial correlations of 1316 metabolites with 4 diet quality indexes, adjusting for age, body mass index, smoking, energy intake, education, and physical activity. We pooled estimates across studies with the use of fixed-effects meta-analysis with Bonferroni correction for multiple comparisons, and conducted metabolic pathway analyses. RESULTS: The HEI-2010, aMED, HDI, and BSD were associated with 23, 46, 23, and 33 metabolites, respectively (17, 21, 11, and 10 metabolites, respectively, were chemically identified; r-range: -0.30 to 0.20; P = 6 x 10(-15) to 8 x 10(-6)). Food-based diet indexes (HEI-2010, aMED, and BSD) were associated with metabolites correlated with most components used to score adherence (e.g., fruit, vegetables, whole grains, fish, and unsaturated fat). HDI correlated with metabolites related to polyunsaturated fat and fiber components, but not other macro- or micronutrients (e.g., percentages of protein and cholesterol). The lysolipid and food and plant xenobiotic pathways were most strongly associated with diet quality. CONCLUSIONS: Diet quality, measured by healthy diet indexes, is associated with serum metabolites, with the specific metabolite profile of each diet index related to the diet components used to score adherence. This trial was registered at clinicaltrials.gov as NCT00342992.

Need the password to download the full database of studies?

Join our mailing list to get access to this as well as other key resources demonstrating the financial benefits of lifestyle medicine and health improvements:

Employers/Professionals Click Here

Healthcare Providers Click Here

Search and Filter

Press crtl for multiple selections
Range Between Start Year and End Year

We can help to reverse the trend, with the savings going right to your bottom line.

The solvency of our nation is at stake.

Benefits Evidence Database Consulting Resources Contact

Lifestyle Medicine Economic Research Council

The LMERC is a special project of the American College of Lifestyle Medicine, a 501(c)3 non-profit charitable organization dedicated to advancing the field of lifestyle medicine as the foundation of a transformed and sustainable system of healthcare delivery.

facebook Twitter Contact
LM Economic Consortium
© 2022 American College of Lifestyle Medicine. Site By Fusion Media Marketing